Thermal properties of normal and sickled hemoglobin protein
نویسندگان
چکیده
Thermodynamic properties of sickled and normal hemoglobin protein are considered within the framework classical molecular dynamics. Here we have studied specific heat capacity RMSD (Root Mean Square Deviation) both types protein. Our investigation reveals that for oxygenated is higher than those de-oxygenated sickle It also observed values decrease with a rise in temperature.
 BIBECHANA 18 (2021) 140-148
منابع مشابه
Gels of Normal and Sickled Hemoglobin
Electron microscopic studies of the sickling phenomenon have described at least three different structural arrangements of sickled hemoglobin, including empty hexagonal crystals, microtubules, and solid rods. It is unlikely that sickling results in several different polymers, and it is essential to determine the true structure of sickled hemoglobin in order to define the mechanism of molecular ...
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The specific defect in molecules of sickle hemoglobin (HbS) has been known for many years (1), but the nature of the assembled polymers of HbS which distort susceptible erythrocytes remains unclear. Several structural forms of sickled hemoglobin have been observed in electron microscopic studies, including a mat-like arrangement of fibers (2), empty hexagonal crystals (3), microtubules (4), and...
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Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle hemoglobin. The rapid growth of these crystals causing tenting of the cell membrane is responsible for the bizarre distortion of the erythrocytes and presumably for the disease itself.
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Structure of sickled erythrocytes and of sickle-cell hemoglobin fibers.
Deoxyhemoglobin from patients homozygous for sickle-cell anemia (deoxyhb S) aggregates into long straight fibers. These may extend through most of the length of the sickled cell, forming either square or hexagonally packed bundles with lattice constants of 170-180 A. Each fiber is a tube made up of six thin filaments, which are wound around the tubular surface with a helical pitch of about 3000...
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ژورنال
عنوان ژورنال: Bibechana
سال: 2021
ISSN: ['2091-0762', '2382-5340']
DOI: https://doi.org/10.3126/bibechana.v18i1.29750